he team collected fecal samples from infants diagnosed with COVID-19 and compared them with those from healthy controls. Using 16S rRNA gene sequencing, they analyzed gut microbiome composition in both groups. The results showed dysbiosis—a disruption in the balance of gut microbial communities—in the infected infants. Beneficial bacteria such as Faecalibacterium, Clostridium, and Ruminococcus were significantly reduced, while Bifidobacterium, Escherichia, and Streptococcus were more abundant.
The study also found downregulation of immune pathways, including interleukin-17 (IL-17), NOD-like receptors, and Toll-like receptors, which are vital for gut mucosal immunity. This suggests that COVID-19 may weaken gut immune defenses in young children.
"This study is among the first to demonstrate how COVID-19 alters the gut environment and immune function in infants during a critical phase of immune development," said Professor Kim, emphasizing the significance of these findings for early childhood health.
Professor Kwak noted, “Alterations in the gut microbiome during infancy may have lasting effects on immune development. Continued monitoring and research are vital to understand the long-term consequences of these infections.”
The findings emphasize the need for ongoing studies into the enduring effects of COVID-19 on young children, particularly regarding their gut health and immune system development.
Lim Hye Jung, HEALTH IN NEWS TEAM
press@hinews.co.kr